Endocrine Abstracts

Low maternal vitamin D (VD) status is associated with adverse fetal development. However gestational changes in VD metabolites and their relationship with cord concentrations are unclear.The plasma concentration of 25-hydroxyvitamin D3 (25(OH)D3) was measured using UPLC-MS/MS, and free 25(OH)D and vitamin D binding protein (DBP) concentrations were measured by ELISA. Plasma samples were collected longitudinally from women resident i...

Fibroblast growth factor-23 (FGF23), a phosphate-regulating hormone is elevated in hypophosphataemic syndromes and is a predictor of mortality in patients with kidney disease. Recent findings demonstrate iron deficiency as a potential mediator of FGF23 expression and murine studies have shown in utero effects of maternal iron deficiency on FGF23 and phosphate (P) metabolism and bone formation (Clinkenbeard, JBMR, 2013).The aim of the cu...

Objectives: To assess antenatal and individual-level predictors of thyroid function across two longitudinal cohorts of children.Methods: Data were taken from two cohorts i) CATSII: 5-10 year-old children enrolled in the CATS (Controlled Antenatal Thyroid Screening) study II from the UK ii) ‘PAX8’: Children from the ENID (Early Nutrition and Immune Development) trial, a pregnancy and infant supplementation trial in The Gambia (Africa) recruited ...